The NYTimes has an interesting article discussing the findings of a Parkinson's Disease researcher.
"Scientific discoveries can be serendipitous, and so it was when Jay L. Alberts, then a Parkinson’s disease researcher at Emory University in Atlanta, mounted a tandem bike with Cathy Frazier, a Parkinson’s patient. The two were riding the 2003 RAGBRAI bicycle tour across Iowa, hoping to raise awareness of the neurodegenerative disease and “show people with Parkinson’s that you don’t have to sit back and let the disease take over your life,” Dr. Alberts said.
But something unexpected happened after the first day’s riding. One of Ms. Frazier’s symptoms was micrographia, a condition in which her handwriting, legible at first, would quickly become smaller, more spidery and unreadable as she continued to write. After a day of pedaling, though, she signed a birthday card with no difficulty, her signature “beautifully written,” Dr. Alberts said. She also told him that she felt as if she didn’t have Parkinson’s."
The article goes on to propose "forced" exercise, that is exercise that is performed at an intensity higher than the patient would normally have chosen, may have significant beneficial effects on Parkinson's Disease characteristics. I think it is important to recognize that this probably has nothing to do with the patient's internal motivation and whether or not the patient is willing or unwilling to do the exercise. This isn't an unethical use of force by any means! But this *is* a wonderfully intelligent and elegant study design that examines the benefits of the least expensive and yet most effective therapies available to us: exercise.
